Does triple-negative phenotype accurately identify basal-like tumour? An immunohistochemical analysis based on 143 ‘triple-negative’ breast cancers
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چکیده
منابع مشابه
Correction: triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival
Correction After the publication of this work [1], we found that there were some mistakes in calculating the percentage of composition in Table 1 (1). Clinicopathologic characteristics of breast cancer subtypes. We are therefore providing the revised Table 1, with the updated data for rows ‘Mucinous carcinoma’, ‘Metaplastic carcinoma’ and ‘Others’. In the sub-content of Table 1, ‘Histological t...
متن کاملImmunohistochemical Differentiation of Triple Negative Breast Cancer.
Based on immunohistochemical staining for the basal markers cytokeratin 5/6 (CK 5/6), cytokeratin 14 (CK 14) and P-cadherin, triple negative tumors (TNT) are divided into two groups: 1) basal-like (BL) positive for one or all three markers; and 2) non basal-like (NBL) negative for all three markers. Even though the different origin of the cells of these two types of tumors implies different bio...
متن کاملp16 expression correlates with basal-like triple-negative breast carcinoma
BACKGROUND Basal-like breast carcinoma (BLBC) has attracted considerable attention over the past few years. It has been suggested that tumours expressing basal markers have a more aggressive clinical behaviour. However, a molecular basis for this disease remains unclear, and it lacks currently used therapeutic targets. Therefore developing a novel treatment strategy is crucial for improving the...
متن کاملAre triple-negative and basal-like breast cancer synonymous?
To the Editor: In a recent issue of Clinical Cancer Research, Dent and colleagues (1) have reported on the prognostic significance of estrogen negative, progesterone negative, and HER2 negative (triple-negative) class in a large cohort of breast cancer patients. Triple-negative tumors are undeniably one of the most relevant subgroups of breast cancer from a medical oncologist’s perspective, giv...
متن کاملThe omics of triple-negative breast cancers.
BACKGROUND Triple-negative breast cancers (TNBC) do not represent a single disease subgroup and are often aggressive breast cancers with poor prognoses. Unlike estrogen/progesterone receptor and HER2 (human epidermal growth factor receptor 2) breast cancers, which are responsive to targeted treatments, there is no effective targeted therapy for TNBC, although approximately 50% of patients respo...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2007
ISSN: 0923-7534
DOI: 10.1093/annonc/mdm360